Publication

Administration route-commended concise organ-selective mRNA transfection (ACCOST) by cyclic disulfide-primed short polyethylenimine.[Nano Today]

2025 Aug          -Nano Today-     [DOI:10.1016/j.nantod.2025.102741]

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Ye, R., Ren, Q., Chang, L., Zhang, S., Deng, C., Cao, L., Shi, M., Lou, B., Meng, F., Du, S., Ren, K., Piao, X., Xu, C.*, Zhong, Z.*

circDesign Algorithm for Designing Synthetic Circular RNA.[bioRxiv]

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2023 Jul          -bioRxiv-     [DOI:10.1101/2023.07.09.548293v3]

Xu, C., Pu, C., Chen, R., Wang, W., Jiang, F., Deng, C., ... & Zhang, L.

Lipopolyplex-formulated mRNA cancer vaccine elicits strong neoantigen-specific T cell responses and antitumor activity.[Sci Adv.]

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2024 Oct          -Sci Adv.-     [DOI:10.1126/sciadv.adn9961]

Fan T#, Xu C# (co-first author), Wu J#, Cai Y, Cao W, Shen H, Zhang M, Zhu H, Yang J, Zhu Z, Ma X, Ren J, Huang L, Li Q, Tang Y, Yu B, Chen C, Xu M, Wang Q, Xu Z, Chen F, Liang S, Zhong Z, Jamroze A, Tang DG, Li H, Dong C.

Polymersome-mediated Cbl-b silencing activates T cells against solid tumors.[Biomater. Sci.]

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2025 Apr          -Biomater. Sci.-     [DOI:10.1039/D5BM00001G]

Cui G, Shao Y, Wang J, Xu C*, Jinping Zhang*, Zhiyuan Zhong*

Conversion of Chemical Drugs into Targeting Ligands on RNA Nanoparticles and Assessing Payload Stoichiometry for Optimal Biodistribution in Cancer Treatment.[RNA NanoMed]

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2024 Jan          -RNA NanoMed-     [DOI:10.59566/ISRNN.2024.0101109]

Xu C, Yin H, Yudhistira T, Li Z, Binzel D,*Guo P*

Algorithm for optimized mRNA design improves stability and immunogenicity.[Nature]

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2023 May         -Nature-     [DOI:10.1038/s41586-023-06127-z]

Zhang, H.#, Zhang, L.#, Lin, A. #, Xu, C. # (co-first author), Li, Z., Liu, K., ... & Huang, L.

Safety, immunogenicity and efficacy of a modified COVID-19 mRNA vaccine, SW-BIC-213, in healthy people aged 18 years and above: interim report of a Phase 3 double-blinded, randomized, parallel controlled clinical trial in Lao PDR (Laos).[EClinicalMedicine]

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2023 Dec         -EClinicalMedicine-     [DOI:0.1016/j.eclinm.2023.102372]

Yi Fang, Jing-Xin Li, Davone Duangdany, Yang Li, Xi-Lin Guo, Chanthala Phamisith, Ming-Yun Shen, Bo Yu, Bin Luo, Yu-Zhu Wang, Si-Jun Liu, Fan-Fan Zhao, Cong-Cong Xu, Xu-Hui Qiu, Rong-Juan Pei, Jie Wang, Haifa Shen, Wu-Xiang Guan, Hang-Wen Li, Mayfong Mayxay

Regulation of reversible conformational change, size switching, and immunomodulation of RNA nanocubes.[RNA]

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2021 Sep         -RNA-     [DOI:10.1261/rna.078718.121. ]

Carcache PJ, Guo S, Li H, Zhang K, Xu C, Chiu W, Guo P.

Tuning the size, shape and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation.[WIREs Nanomedicine and Nanobiotechnology]

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2019 Aug         -WIREs Nanomedicine and Nanobiotechnology-     [DOI:10.1002/wnan.1582]

Guo S., Xu C., Yin H., Hill J., Pi F., Guo P.

3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution.[Nano Research]

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2020 Dec         -Nano Research-     [DOI:10.1007/s12274-020-2996-1]

Xu, C., Zhang, K., Yin, H., Li, Z., Krasnoslobodtsev, A., Zheng, Z., Ji, Z., Guo, S., Li, S., Chiu, W. and Guo, P.

Safety and Immunogenicity of SW-BIC-213, a Modified COVID-19 Lipo-Polyplex Mrna Vaccine, in Laotian Healthy Adults Aged 18 Years and Above: a Phase 1/2 Trial[Openalex]

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2023 Dec         -Openalex-     [DOI:10.1101/2023.09.11.23295344]

Chen, Y., Li, J., Duangdany, D., Phamisith, C., Yu, B., Lan, S., Jin, L., Lv, D., Li, Y., Luo, B., Han, P., Wu, J., Wang, Y., Xu, C., Shen, M., Zhao, F., Liu, P., Pei, R., Shen, H., Guan, W., Li, H., Mayxay, M.

RNA nanoparticles as rubber for compelling vessel extravasation to enhance tumor targeting and for fast renal excretion to reduce toxicity.[ACS Nano]

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2020 Sept         -ACS Nano-     [DOI:10.1021/acsnano.0c04863]

Ghimire C, Wang H, Li H, Vieweger M, Xu C, Guo P.

Construction of RNA nanotubes.[Nano Research]

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2019 Aug         -Nano Research-     [DOI:10.1007/s12274-019-2463-z]

Li H., Wang S., Ji Z., Xu C., Shlyakhtenko L.S. and Guo P.

Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping.[J Control Release]

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2019 Aug         -J Control Release-     [DOI:10.1016/j.jconrel.2019.08.021]

Zheng Z, Li Z, Xu C, Guo B, Guo P.

Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133.[Mol Ther.]

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2019 Jul         -Mol Ther.-     [DOI:10.1016/j.ymthe.2019.04.018]

Yin H, Xiong G, Guo S, Xu C, Xu R, Guo P, Shu D.

Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression.[Redox Biol.]

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2019 Feb         -Redox Biol.-     [DOI:10.1016/j.redox.2018.101085]

Xu Y, Pang L, Wang H, Xu C, Shah H, Guo P, Shu D, Qian SY.

Photo-controlled release of paclitaxel and model drugs from RNA pyramids.[Nano Res.]

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2018 Sept         -Nano Res.-     [DOI:10.1007/s12274-018-2174-x]

Xu C, Li H, Zhang K, Binzel DW, Yin H, Chiu W, Guo P.

Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy.[Cancer Lett.]

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2018 Feb         -Cancer Lett.-     [DOI:10.1016/j.canlet.2017.09.043]

Xu C, Haque F, Jasinski DL, Binzel DW, Shu D, Guo P.

Self-Assembled DNA Nanocentipede as Multivalent Drug Carrier for Targeted Delivery.[ACS Appl Mater Interfaces]

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2016 Sept         -ACS Appl Mater Interfaces-     [DOI:10.1021/acsami.6b08210]

Li W, Yang X, He L, Wang K, Wang Q, Huang J, Liu J, Wu B, Xu C.

Publication

Administration route-commended concise organ-selective mRNA transfection (ACCOST) by cyclic disulfide-primed short polyethylenimine.[Nano Today]

circDesign Algorithm for Designing Synthetic Circular RNA.[bioRxiv]

Lipopolyplex-formulated mRNA cancer vaccine elicits strong neoantigen-specific T cell responses and antitumor activity.[Sci Adv.]

Polymersome-mediated Cbl-b silencing activates T cells against solid tumors.[Biomater. Sci.]

Conversion of Chemical Drugs into Targeting Ligands on RNA Nanoparticles and Assessing Payload Stoichiometry for Optimal Biodistribution in Cancer Treatment.[RNA NanoMed]

Algorithm for optimized mRNA design improves stability and immunogenicity.[Nature]

Safety, immunogenicity and efficacy of a modified COVID-19 mRNA vaccine, SW-BIC-213, in healthy people aged 18 years and above: interim report of a Phase 3 double-blinded, randomized, parallel controlled clinical trial in Lao PDR (Laos).[EClinicalMedicine]

Regulation of reversible conformational change, size switching, and immunomodulation of RNA nanocubes.[RNA]

Tuning the size, shape and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation.[WIREs Nanomedicine and Nanobiotechnology]

3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution.[Nano Research]

Safety and Immunogenicity of SW-BIC-213, a Modified COVID-19 Lipo-Polyplex Mrna Vaccine, in Laotian Healthy Adults Aged 18 Years and Above: a Phase 1/2 Trial[Openalex]

RNA nanoparticles as rubber for compelling vessel extravasation to enhance tumor targeting and for fast renal excretion to reduce toxicity.[ACS Nano]

Construction of RNA nanotubes.[Nano Research]

Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping.[J Control Release]

Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133.[Mol Ther.]

Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression.[Redox Biol.]

Photo-controlled release of paclitaxel and model drugs from RNA pyramids.[Nano Res.]

Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy.[Cancer Lett.]

Self-Assembled DNA Nanocentipede as Multivalent Drug Carrier for Targeted Delivery.[ACS Appl Mater Interfaces]

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